コデインそのものはμ-オピオイド受容体に弱い親和力を示す。主要な鎮痛作用はμ-オピオイド受容体へのモルヒネの親和性による。しかし他の作用または副作用は他のオピオイド受容体への作用による。

Lung Problems. Promethazine/phenylephrine/codeine shouldn't be made use of if you have intense bronchial asthma, problems breathing, or other lung troubles. Promethazine/phenylephrine/codeine might make these ailments even worse.

These persons transform codeine into its Energetic metabolite, morphine, a lot more fast and completely than other people. This rapid conversion-leads to better than expected serum morphine amounts. Even at labeled dosage regimens, individuals who are extremely-rapid metabolizers could have daily life-threatening or fatal respiratory melancholy or experience signs of overdose (for example Intense sleepiness, confusion, or shallow respiratory). (See OVERDOSAGE). Kids with obstructive sleep apnea who will be treated with codeine for article-tonsillectomy and/or adenoidectomy suffering may very well be especially sensitive for the respiratory depressant outcomes of codeine which has been speedily metabolized to morphine. Codeine is contraindicated for write-up-operative pain administration in all pediatric patients undergoing tonsillectomy and/or adenoidectomy. (See CONTRAINDICATIONS). When prescribing codeine-made up of drugs, healthcare suppliers should pick the cheapest productive dose for that shortest length of time and tell individuals and caregivers about these pitfalls as well as the indications of morphine overdose.

The presence of the polymorphism in CYP2D6 brings about non-performing enzyme variant and could be connected with minimized drug mtabolism or diminished therapeutic response when dealt with with codeine.

Tell your health practitioner When you've got at any time had any unconventional or allergic reaction to this medication or almost every other medicines. Also tell your overall health care Qualified Should you have any other sorts of allergic reactions, like to foods, dyes, preservatives, or animals. For non-prescription goods, go through the label or package elements cautiously.

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Treatment: The remedy of overdosage with promethazine and codeine is actually symptomatic and supportive. Only in cases of extreme overdosage or personal sensitivity do very important indications together with respiration, pulse, hypertension, temperature, and EKG need to be monitored. Activated charcoal orally or by lavage may be presented, or sodium or magnesium sulfate orally to be a cathartic. Notice really should be offered to your reestablishment of adequate respiratory Trade by means of provision of the patent airway and institution of assisted or managed ventilation.

When you find yourself having this medication, it is especially essential that the healthcare Qualified know For anyone who is using any of the medicines listed down below. The next interactions have already been picked on the basis in their potential significance and so are not automatically all-inclusive.

The risk for severe respiratory problems is bigger when You begin this medication and after a dose improve, or if you take the incorrect dose/energy. Using this medication with alcohol or other medications that could potentially cause drowsiness or respiratory challenges may possibly result in very significant Unintended effects, which include Demise. Also, other remedies can have an affect on the removal of codeine from a human body, which can influence how codeine read more functions.

Narcotics may develop adverse reactions which may obscure the scientific study course of individuals with head accidents.

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Throw away expired, undesirable, or unused promethazine/phenylephrine/codeine without delay by taking your medicine to an authorized DEA-registered collector or drug get back again software.

Pregnancy. Promethazine/phenylephrine/codeine may well cause harm to an unborn child. Notify your Health care service provider When you are or strategy to become pregnant. Your healthcare provider will advise you if you need to get promethazine/phenylephrine/codeine if you are Expecting or endeavoring to get Expecting.

If patients of any age are known to become CYP2D6 ultra-immediate metabolizers, which implies their bodies change codeine or tramadol into their active sorts speedier and more totally than usual, they must not use codeine or tramadol.